The former Potosi Brewery operated for 120 years, from 1852 until 1972. When it closed, the buildings were left to deteriorate, creating an eyesore, a danger and a health hazard. As part of an economic development project, the building was restored, housing among other things the National Brewery Museum as well as an Interpretive Center for the Great River Road. The Potosi Brewery is the only non-profit brewery in the country with all profits benefiting other non-profit organizations.